Thrombocytosis: A Disease or a Response?

Abstract

Objective: The aim of our study is to investigate the etiologic causes of thrombocytosis and check the presence of JAK2 mutation in these cases of thrombocytosis, retrospectively.

Methodology: This is a cross-sectional study conducted at Chughtai Institute of Pathology, Lahore from January to July 2025. A total of 100 patients with persistent thrombocytosis were included in the study. Both male and female patients above 18 years of age were included in the study. Already diagnosed cases were excluded along with patients on any sort of chemotherapy. A detailed history of the patient was taken, and all aspects of their present illness and previous medical history were analyzed. CBC counts and JAK2 mutation were analyzed and data were analyzed using SPSS.

Results: In our study a total of 100 patients were recruited which consisted of 46 females and 54 males. The average age was 53.4 years (range 24 to 76 years). The presence of JAK2 V617F mutation was detected in the total of 44 patients indicating primary thrombocytosis whereas 56 patients had secondary thrombocytosis.

Conclusion: It is essential to investigate thrombocytosis especially in old age, as it might be the only sign indicating a hidden MPN. Thereby, it is imperative that thrombocytosis should not be overlooked and must be thoroughly investigated